![]() Creatine is stored in high concentrations in both skeletal and cardiac muscle as both creatine and phosphocreatine, which is available for immediate regeneration of ATP during short bouts of intense exercise. This reaction uses more methyl groups from SAM than any other methylation reaction ( 1). Once synthesized, GAA can be methylated by S-adenosylmethionine (SAM) to creatine and S-adenosylhomocysteine, which is quickly metabolized to homocysteine. This may have implications for energy metabolism and should be considered when using creatinine as a diagnostic tool in dogs.Ĭreatine, an essential nitrogenous compound, is synthesized from the amino acids glycine and arginine to produce ornithine and guanidinoacetate (GAA). These data suggest that when creatine, carnitine and choline are top-dressed for 7 days, plasma creatine is rapidly absorbed and remains elevated up to 6 h post-meal. ![]() ![]() Plasma creatinine concentrations were higher in dogs fed CCC from 60 to 180 min compared to all other treatments. Plasma creatine concentrations were higher in dogs fed CCC (103 ± 10 μmol/L) compared to MET (72 ± 7 μmol/L) at fasted ( P < 0.05) and higher compared to all other treatments from 15 to 360 min post-meal ( P < 0.05). Creatine and creatinine were analyzed using HPLC and data analyzed using PROC GLIMMIX in SAS. On day 7, cephalic catheters were placed and blood samples were collected before being fed (fasted) and up to 6 h post-meal. Eight adult Beagles were fed one of the four diets for 7 days in a Latin Square design with no washout period. The objective of the present investigation was to define the postprandial plasma creatine and creatinine response in dogs fed a commercial diet (CON) formulated for adult dogs, top-dressed with a combination of creatine (9.6 g/kg dry matter, DM), carnitine (2.13 g/kg DM) and choline (0.24 g/kg DM CCC), methionine (2.6 g/kg DM MET), or taurine (0.7 g/kg DM TAU). ![]() 2AlzChem Trostberg GmbH, Trostberg, GermanyĬreatine is a nitrogenous compound essential for cellular energy homeostasis found in animal protein however, when heat-processed for pet food, creatine is degraded to creatinine, which is not metabolically active and excreted in urine.1Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada. ![]()
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